Structure-activity relationships of a series of novel (piperazinylbutyl) thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo [b] thien-3-yl)-1-piperazinyl] …

…, MR Szewczak, AT Woods-Kettelberger…

文献索引：Hrib, Nicholas J.; Jurcak, John G.; Bregna, Deborah E.; Burgher, Kendra L.; Hartman, Harold B.; Kafka, Sharon; Kerman, Lisa L.; Kongsamut, Sam; Roehr, Joachim E.; Szewczak, Mark R.; Woods-Kettelberger, Ann T.; Corbett, Roy Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 4044 - 4057

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被引用次数: 29

摘要

HP-236 (3-[4-[4-(6-Fluorobenzo [b] thien-3-yl)-1-piperazinyl] butyl]-2, 5, 5-trimethyl-4- thiazolidinone maleate; P-9236)(54) displayed a pharmacological profile indicative of potential atypical antipsychotic activity. A series of piperazinyl butyl thiazolidinones structurally related to this compound were prepared and evaluated in vitro for dopamine D2 and serotonin 5HT2 and 5HT1A receptor affinity. The compounds were examined in vivo ...