Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: synthesis and structure-activity relationships

M Chihiro, H Nagamoto, I Takemura…

文献索引：Chihiro; Nagamoto; Takemura; Kitano; Komatsu; Sekiguchi; Tabusa; Mori; Tominaga; Yabuuchi Journal of Medicinal Chemistry, 1995 , vol. 38, # 2 p. 353 - 358

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被引用次数: 97

摘要

Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3, 4-diethoxyphenyl) thiazol ...