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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Studies on anti-Candida agents with a pyrrole moiety. Synthesis and microbiological activity of some 3-aminomethyl-1, 5-diaryl-2-methyl-pyrrole derivatives

F Cerreto, A Villa, A Retico, M Scalzo

文献索引：Cerreto; Villa; Retico; Scalzo European Journal of Medicinal Chemistry, 1992 , vol. 27, # 7 p. 701 - 708

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被引用次数: 16

摘要

Abstract The synthesis and anti-Candida activity of some 3-aminomethyl-1, 5-diaryl-2-methyl- pyrrole derivatives are reported. Some derivatives show a rather strong anti-Candida activity. On the basis of experimental results, microbiological activity of 1, 5-diarylpyrroles appears to be mainly related to aminic nitrogen lone pair availability of C3 substituent of the pyrrole nucleus. The C5 and N1 substituents play an important role in modulating ...

四氢吡咯结构式

甲醛结构式

未登录结构式

~30%

1-(2,4-dichlorophenyl)-2-methyl-5-phenyl-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

1-(2,4-dichloro...

2,4-二氯苯胺结构式

2,4-二氯苯胺

~%

1-(2,4-dichlorophenyl)-2-methyl-5-phenyl-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

1-(2,4-dichloro...

1-苯基-1,4-戊二酮结构式

1-苯基-1,4-戊二酮

~%

1-(2,4-dichlorophenyl)-2-methyl-5-phenyl-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

1-(2,4-dichloro...

1-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-2-methyl-1H-pyrrol-3-yl)-N,N,N-trimethylmethanaminium iodide结构式

1-(5-(4-chlorop...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~30%

N-[[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-2-methylpyrrol-3-yl]methyl]aniline结构式

N-[[5-(4-chloro...

1-(4-氯苯基)戊烷-1,4-二酮结构式

1-(4-氯苯基)戊烷-1,4-二酮

~%

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-2-methyl-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

5-(4-chlorophen...

2,4-二氯苯胺结构式

2,4-二氯苯胺

~%

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-2-methyl-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

5-(4-chlorophen...

四氢吡咯结构式

甲醛结构式

未登录结构式

~47%

5-(4-chlorophenyl)-2-methyl-1-(4-nitrophenyl)-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

5-(4-chlorophen...

1-(4-氯苯基)戊烷-1,4-二酮结构式

1-(4-氯苯基)戊烷-1,4-二酮

~%

5-(4-chlorophenyl)-2-methyl-1-(4-nitrophenyl)-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

5-(4-chlorophen...

对硝基苯胺结构式

对硝基苯胺

~%

5-(4-chlorophenyl)-2-methyl-1-(4-nitrophenyl)-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

5-(4-chlorophen...

未登录结构式

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~20%

N-[[5-(4-chlorophenyl)-2-methyl-1-phenylpyrrol-3-yl]methyl]aniline结构式

N-[[5-(4-chloro...

未登录结构式

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~20%

N-[[1-(2,4-dichlorophenyl)-2-methyl-5-phenylpyrrol-3-yl]methyl]aniline结构式

N-[[1-(2,4-dich...

N-甲基哌嗪结构式

甲醛结构式

2-(4-chlorophenyl)-5-methyl-1-phenylpyrrole结构式

2-(4-chlorophen...

~59%

1-[[5-(4-chlorophenyl)-2-methyl-1-phenylpyrrol-3-yl]methyl]-4-methylpiperazine结构式

1-[[5-(4-chloro...

1-(4-氯苯基)戊烷-1,4-二酮结构式

1-(4-氯苯基)戊烷-1,4-二酮

~%

1-[[5-(4-chlorophenyl)-2-methyl-1-phenylpyrrol-3-yl]methyl]-4-methylpiperazine结构式

1-[[5-(4-chloro...

四氢吡咯结构式

甲醛结构式

2-(4-chlorophenyl)-5-methyl-1-phenylpyrrole结构式

2-(4-chlorophen...

~41%

5-(4-chlorophenyl)-2-methyl-1-phenyl-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

5-(4-chlorophen...

1-(4-氯苯基)戊烷-1,4-二酮结构式

1-(4-氯苯基)戊烷-1,4-二酮

~%

5-(4-chlorophenyl)-2-methyl-1-phenyl-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

5-(4-chlorophen...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

5-(4-chlorophenyl)-2-methyl-1-phenyl-3-(pyrrolidin-1-ylmethyl)pyrrole结构式

5-(4-chlorophen...

甲醛结构式

2-(4-chlorophenyl)-5-methyl-1-phenylpyrrole结构式

2-(4-chlorophen...

二甲胺结构式

~75%

1-[5-(4-chlorophenyl)-2-methyl-1-phenylpyrrol-3-yl]-N,N-dimethylmethanamine结构式

1-[5-(4-chlorop...

1-(4-氯苯基)戊烷-1,4-二酮结构式

1-(4-氯苯基)戊烷-1,4-二酮

~%

1-[5-(4-chlorophenyl)-2-methyl-1-phenylpyrrol-3-yl]-N,N-dimethylmethanamine结构式

1-[5-(4-chlorop...

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~%

1-[5-(4-chlorophenyl)-2-methyl-1-phenylpyrrol-3-yl]-N,N-dimethylmethanamine结构式

1-[5-(4-chlorop...

咪唑结构式

未登录结构式

~51%

1-[[5-(4-chlorophenyl)-2-methyl-1-phenylpyrrol-3-yl]methyl]imidazole结构式

1-[[5-(4-chloro...

1-(4-氯苯基)戊烷-1,4-二酮结构式

1-(4-氯苯基)戊烷-1,4-二酮

2,4,6-三溴苯胺结构式

2,4,6-三溴苯胺

~62%

2-(4-chlorophenyl)-5-methyl-1-phenylpyrrole结构式

2-(4-chlorophen...

咪唑结构式

1-(1-(4-chlorophenyl)-2-methyl-5-phenyl-1H-pyrrol-3-yl)-N,N,N-trimethylmethanaminium iodide结构式

1-(1-(4-chlorop...

~66%

1-[[1-(4-chlorophenyl)-2-methyl-5-phenylpyrrol-3-yl]methyl]imidazole结构式

1-[[1-(4-chloro...