Journal of the American Chemical Society

Insertion of 1-chloro-1-lithioalkenes into organozirconocenes. A versatile synthesis of stereodefined unsaturated systems

A Kasatkin, RJ Whitby

文献索引：Kasatkin, Aleksandr; Whitby, Richard J. Journal of the American Chemical Society, 1999 , vol. 121, # 30 p. 7039 - 7049

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被引用次数: 76

摘要

Hydrozirconation of alkenes and alkynes, followed by insertion of 1-halo-1-lithio-1-alkenes, generated in situ by lithium tetramethylpiperidide deprotonation of vinyl halides, affords vinylzirconocene species which may be further elaborated. The method provides easy access to many structures including terminal (3 E)-and (3 Z)-1, 3-dienes and (3 E, 5 E)-and (3 Z, 5 E)-1, 3, 5-trienes, and internal (E, Z)-dienes,(E, Z, E)-trienes, and (1 E, 3 Z)-1, 3- ...