An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors

JM McKenna, F Halley, JE Souness…

文献索引：Gacek, Michel; Undheim, Kjell Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 8 p. 691 - 696

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被引用次数: 77

摘要

... Chem. , 2002, 45 (11), pp 2173–2184. DOI: 10.1021/jm011132l. Publication Date (Web): April 27, 2002. Copyright © 2002 American Chemical Society. ... MCMS applies a scoring function, controlled by a series of weights, to drive the monomer selection toward a solution which best ...