Abstract The E-configurated 3-(ω-iodoalkylidene)-piperidin-2-ones 1a-e were prepared from the corresponding ω-tert-butyldimethylsilyloxyalkanals 5a-e by aldol condensation with N- tert-butyloxycarbonylpiperidone, subsequent silyl deprotection and iodo-dehydroxylation. In the presence of tributylstannane as the reducing agent and of triethylborane as the initiator the iodides underwent a reductive radical cyclization to the corresponding products rac-9a ...
![6-[tert-butyl(dimethyl)silyl]oxyhexanal结构式](https://image.chemsrc.com/caspic/268/118794-69-7.png)
![6-{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylhexanal结构式](https://image.chemsrc.com/caspic/079/911369-52-3.png)
![(E)-3-(6-{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylhexylidene)piperidin-2-one结构式](https://image.chemsrc.com/caspic/389/911369-57-8.png)
