Coaxing a Pyridine Nucleus To Give Up Its Aromaticity: Synthesis and Pharmacological Characterization of Novel Conformationally Restricted Analogues of Nicotine …

…, R Moaddel, R Yamaguchi, K Jozwiak…

文献索引：Sarkar, Tarun K.; Basak, Sankar; Wainer, Irving; Moaddel, Ruin; Yamaguchi, Rika; Jozwiak, Krzysztof; Chen, Hui-Ting; Lin, Chun-Cheng Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6691 - 6701

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被引用次数: 15

摘要

A series of novel nicotine and anabasine related conformationally restricted compounds including those with π-bonds in the connecting tether were synthesized following the hitherto unprecedented phenylsulfanyl group assisted generation of pyridine o- quinodimethane intermediates and their trapping by an intramolecular Diels-Alder reaction. Pharmacological characterization of some of these analogues at activating α3β4 nAChRs ...