Tetrahedron Letters

Base-free monosulfonylation of amines using tosyl or mesyl chloride in water

A Kamal, JS Reddy, EV Bharathi, D Dastagiri

文献索引：Kamal, Ahmed; Reddy, J. Surendranadha; Bharathi, E. Vijaya; Dastagiri Tetrahedron Letters, 2008 , vol. 49, # 2 p. 348 - 353

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被引用次数: 31

摘要

Sulfonamides are a diverse group of pharmaceutically important compounds 1 and 2 widely used as antibacterial, anticancer, anticonvulsant, antiinflammatory and antiviral agents and HIV protease inhibitors. Examples of recently approved drugs possessing a sulfonamide include the antihypertensive agent bosentan, 3 the antiviral HIV protease inhibitor amprenavir 4 and the phosphodiesterase-5 inhibitor sildenafil. 5 In addition, numerous sulfonamide ...