Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1, 4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition

…, D Fusar, M Grossoni, M Menichincheri…

文献索引：Cozzi, Paolo; Carganico, Germano; Fusar, Domenico; Grossoni, Mauro; Menichincheri, Maria; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2964 - 2972

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被引用次数: 104

摘要

A series of derivatives of 4-phenyl-l, 4-dihydropyridine bearing imidazol-1-yl or pyridin-3-yl moieties on the phenyl ring were synthesized with the aim of combining Ca2+ antagonism and thromboxane A2 (TxA2) synthase inhibition in the same molecule. Some of these compounds showed significant combined Ca2+ antagonism and TxA2 synthase inhibition in vitro, while others showed only one single activity. Structural requirements for significant ...