Synthesis and activity studies of analogues of the rat selective toxicant norbormide

D Rennison, S Bova, M Cavalli, F Ricchelli…

文献索引：Rennison, David; Bova, Sergio; Cavalli, Maurizio; Ricchelli, Fernanda; Zulian, Alessandra; Hopkins, Brian; Brimble, Margaret A. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 8 p. 2963 - 2974

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被引用次数: 21

摘要

Norbormide [5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)-5-norbornene-2, 3- dicarboximide](NRB, 1), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents and mammals. A series of NRB- related analogues were prepared to investigate the structural features responsible for, and the in vitro biological markers indicative of, in vivo lethality of the parent molecule in rats. ...