Chemotherapy of leishmaniasis. Part IX: Synthesis and bioevaluation of aryl substituted ketene dithioacetals as antileishmanial agents

…, SN Suryawanshi, M Mittal, P Vishwakarma…

文献索引：Kumar, Santosh; Tiwari, Avinash; Suryawanshi, S. N.; Mittal, Monika; Vishwakarma, Preeti; Gupta, Suman Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6728 - 6730,3

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被引用次数: 6

摘要

A new series of aryl substituted ketene dithioacetals 6a–h was synthesized and evaluated for their in vitro and in vivo antileishmanial activity against Leishmania donovani. Two compounds exhibited significant in vitro activity against intracellular amastigotes of L. donovani with IC50 values 3.56 and 5.12 μM and were found promising as compared with reference drug, miltefosine. On the basis of good Selectivity Indices (SI), they were further ...