Molecular recognition of DNA by rigid [N]-polynorbornane-derived bifunctional intercalators: synthesis and evaluation of their binding properties

…, RA Russell, RN Warrener, F Hollfelder…

文献索引：Van Vliet, Liisa D.; Ellis, Tom; Foley, Patrick J.; Liu, Ligong; Pfeffer, Frederick M.; Russell, Richard A.; Warrener, Ronald N.; Hollfelder, Florian; Waring, Michael J. Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2326 - 2340

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被引用次数: 42

摘要

We have exploited the concept of multivalency in the context of DNA recognition, using novel chemistry to synthesize a new type of bis-intercalator with unusual sequence- selectivity. Bis-intercalation has been observed previously, but design principles for de novo construction of such molecules are not known. Our compounds feature two aromatic moieties projecting from a rigid, polynorbornane-based scaffold. The length and character ...