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Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones

…, G Murugananthan, R Venkateshperumal

文献索引:Alagarsamy, Veerachamy; Murugananthan, Gopal; Venkateshperumal, Ramachandran Biological and Pharmaceutical Bulletin, 2003 , vol. 26, # 12 p. 1711 - 1714

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被引用次数: 92

摘要

A series of novel 2-methyl-3-substituted quinazolin-4-(3H)-ones have been synthesized by treating (2-methyl-4-oxo-3H-quinazolin-3-yl) dithiocarbamic acid methyl ester with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The compounds synthesized were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds VA2, VA3 ...