Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: potential therapeutics for type II diabetes

…, MJ Lilly, DJ Owen, LJ D'Souza, XQ Tang…

文献索引：Pei, Yazhong; Lilly, Michael J.; Owen, David J.; D'Souza, Lawrence J.; Tang, Xiao-Qing; Yu, Jinghua; Nazarbaghi, Ramina; Hunter, Andrew; Anderson, Christen M.; Glasco, Susan; Ede, Nicholas J.; James, Ian W.; Maitra, Uday; Chandrasekaran; Moos, Walter H.; Ghosh, Soumitra S. Journal of Organic Chemistry, 2003 , vol. 68, # 1 p. 92 - 103

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被引用次数: 31

摘要

Type II diabetes mellitus is a chronic metabolic disorder that can lead to serious cardiovascular, renal, neurologic, and retinal complications. While several drugs are currently prescribed to treat type II diabetes, their efficacy is limited by mechanism-related side effects (weight gain, hypoglycemia, gastrointestinal distress), inadequate efficacy for use as monotherapy, and the development of tolerance to the agents. Consequently, ...