Synthesis and evaluation of N-acetyl-l-tyrosine based compounds as PPARα selective activators

…, U Ramachandran, S Raichur, R Chakrabarti…

文献索引：Kumar, Rakesh; Ramachandran, Uma; Raichur, Suryaprakash; Chakrabarti, Ranjan; Jain, Rahul European Journal of Medicinal Chemistry, 2007 , vol. 42, # 4 p. 503 - 510

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被引用次数: 6

摘要

The development of type 2 diabetes in obese individuals is linked to lipid accumulation in non-adipose tissues. A series of N-acetyl-l-tyrosine derivatives were synthesized and evaluated for PPAR transactivation. Compounds 4d and 4f were found to show better PPARα transactivation as compared to PPARγ. Molecular docking analysis was carried out to study their important interactions with the active site of PPARα.