Tetrahedron letters

Design, synthesis and utilization of a novel coupling reagent for the preparation of O-alkyl hydroxamic acids

ND Kokare, RR Nagawade, VP Rane, DB Shinde

文献索引：Kokare, Nagnnath D.; Nagawade, Rahul R.; Rane, Vipul P.; Shinde, Devanand B. Tetrahedron Letters, 2007 , vol. 48, # 25 p. 4437 - 4440

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被引用次数: 13

摘要

An efficient novel reagent, phosphoric acid diethyl ester 2-phenyl-benzimidazol-1-yl ester, was designed, and synthesized and its applicability was demonstrated for the preparation of O-alkyl hydroxamic acids. The O-alkyl hydroxamic acids of N-protected amino acids were also synthesized. The enantiomeric purity of the synthesized compounds were measured using chiral HPLC and the degree of racemization was found to be negligible.