Bioorganic & medicinal chemistry

Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

SN Mokale, D Lokwani, DB Shinde

文献索引：Mokale, Santosh N.; Lokwani, Deepak; Shinde, Devanand B. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 9 p. 3119 - 3127

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被引用次数: 12

摘要

A novel series of substituted imidazol-5-ones were designed, synthesized and evaluated for in vitro reverse transcriptase (RT) inhibition activity using reverse transcriptase assay kit (Roche, Colorimetric). It has been observed from in vitro screening that newly synthesized compounds possess RT inhibitory activity. Docking study was performed to study the binding orientation and affinity of synthesized compounds for RT enzyme.