Atom-efficient assembly of 1, 5-oxygen-bridged medium-sized carbocycles by sequential combination of a Ru-catalyzed alkyne-alkene coupling and a Prins-type …

F López, L Castedo, JL Mascareñas

文献索引：Lopez, Fernando; Castedo, Luis; Mascarenas, Jose L. Journal of the American Chemical Society, 2002 , vol. 124, # 16 p. 4218 - 4219

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被引用次数: 53

摘要

Ruthenium-catalyzed coupling of readily accessible 1-trimethylsilyl-1-alkyn-3-ols to allyl ethyl ether followed by in situ ketalization and Lewis-acid induced cyclization affords 1, 5- oxygen-bridged eight-and nine-membered carbocycles, products which are difficult to construct with previously published strategies.