Orally bioavailable competitive CCR5 antagonists

…, C Beerli, C Bruns, E Francotte, M Luyten…

文献索引：Thoma, Gebhard; Nuninger, Francois; Schaefer, Marc; Akyel, Kayhan G.; Albert, Rainer; Beerli, Christian; Bruns, Christian; Francotte, Eric; Luyten, Marcel; MacKenzie, Duncan; Oberer, Lukas; Streiff, Markus B.; Wagner, Trixie; Walter, Hansrudolf; Weckbecker, Gisbert; Zerwes, Hans-Guenter Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1939 - 1955

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被引用次数: 45

摘要

The chemokine receptor CCR5 plays an important role in inflammatory and autoimmune disorders as well as in transplant rejection by affecting the trafficking of effector T cells and monocytes to diseased tissues. Antagonists of CCR5 are believed to be of potential ...