Abstract 2, 6-Dihydroxy-4-methyl-3-pyridinecarbonitrile is converted via its 2, 6-dichloro analog into the corresponding 2-amino-6-chloro, 2-chloro-6-amino, and 2, 6-diamino derivatives. The last reacts with benzene-sulfonyl chloride to yield a tris-sulfonyl derivative, the structure of which is demonstrated by X-ray analysis.