Abstract–N-Formylenamides of isoquinoline (6) were obtained from N-[2-(2-acyl-4, 5- dimethoxyphenyl) ethyl] formamides (5) by cyclization in the presence of catalytic amount of p-toluensulfonic acid. The starting keto formamides (5) were obtained by acylation of a N-[2- (3, 4-dimethoxyphenyl) ethyl] formamides (1) with carboxylic acids or their anhydrides in polyphosphoric acid (PPA).