Synthesis and Evaluation of Indatraline??Based Inhibitors for Trypanothione Reductase

…, P Kiuru, AJ Durie, NJ Westwood, AH Fairlamb

文献索引：Walton, Jeffrey G. A.; Jones, Deuan C.; Kiuru, Paula; Durie, Alastair J.; Westwood, Nicholas J.; Fairlamb, Alan H. ChemMedChem, 2011 , vol. 6, # 2 p. 321 - 328

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被引用次数: 17

摘要

Abstract The search for novel compounds of relevance to the treatment of diseases caused by trypanosomatid protozoan parasites continues. Screening of a large library of known bioactive compounds has led to several drug-like starting points for further optimisation. In this study, novel analogues of the monoamine uptake inhibitor indatraline were prepared and assessed both as inhibitors of trypanothione reductase (TryR) and against the ...