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Alkylation of Substituted Malonic and Cyanoacetic Esters with 2-Diamethylaminomethylpyrrole. A Proposed Synthesis of β-2-Pyrrolealanine1

W Herz, K Dittmer, SJ Cristol

文献索引:Herz; Dittmer Journal of the American Chemical Society, 1948 , vol. 70, p. 503

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被引用次数: 27

摘要

P-2-Thienylalanine3s4t5 and P-2-furylalanine6 have been shown to inhibit microbial growth, presumably due to their structural similarity to phenylalanine. The corresponding nitrogen analog,/3-2-pyrrolealanine, is not described in the literature. As part of a program to correlate the structure of amino acids with their biological activity, it seemed desirable to prepare this substance so that it might be available for microbiological study.