The characteristic odor of the diastereoisomers 1 and 2 of l-(2, 2, 6-trimethylcyclohexyl)-3- hexanol is configuration dependent, the trans-alcohol 1 bcing identified as the sensorily active component. Structure modifications of model lj2, for example substitution on C (2), C (13), and C (14)(ionon numbering) by CH, groups, introduction of double bonds in the 3-or 4- position, and isosteric substitution of C (7) by an 0-atom, leads to analogues revealing an ...
