Discovery and synthesis of novel luteolin derivatives as DAT agonists

J Zhang, X Liu, X Lei, L Wang, L Guo, G Zhao…

文献索引：Zhang, Jiange; Liu, Xianbo; Lei, Xinsheng; Wang, Lei; Guo, Lihe; Zhao, Gang; Lin, Guoqiang Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 22 p. 7842 - 7848

全文：HTML全文

被引用次数: 9

摘要

Luteolin, 5, 7-dihydroxy-2-(3, 4-dihydroxyphenyl)-4H-chromen-4-one, has been proposed and proved to be a novel dopamine transporter (DAT) activator. In order to develop this potential of luteolin, a series of novel luteolin derivatives were designed, synthesized, and evaluated for their DAT agonistic activities, utilizing constructed Chinese hamster ovary (CHO) cell lines stably expressing rat DAT. Biological screening results demonstrated that ...