Tumor inhibitors. XLIII. Solapalmitine and solapalmitenine, two novel alkaloid tumor inhibitors from Solanum tripartitum

SM Kupchan, AP Davies, SJ Barboutis…

文献索引：Kupchan; Davies; Barboutis; Schnoes; Burlingame The Journal of organic chemistry, 1969 , vol. 34, # 12 p. 3888 - 3893

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被引用次数: 40

摘要

An alcoholic extract of Solanum tripartiturn Dunal was found to show significant inhibitory activity when tested in vitro against cells derived from human carcinoma of the nasopharynx (KB). Systematic fractionation led to the separation of solapartine, a liquid alkaloid mixture which possessed significant inhibitory activity against the Walker 256 carcinosarcoma in rats. Further fractionation of solapartine resulted in the separation of two growth-inhibitory ...