Phase transfer catalysis in N??alkylation of the pharmaceutical intermediates phenothiazine and 2??chlorophenothiazine

I Gozlan, D Ladkani, M Halpern…

文献索引：Gozlan; Ladkani; Halpern; et al. Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 2 p. 613 - 614

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被引用次数: 17

摘要

Abstract The N-alkylation of the two title compounds was studied, utilizing phase transfer catalysis (PTC) methods. Very mild reaction conditions were developed, especially for three- carbon N-alkylation. Of special interest is the high-yield synthesis of N-(3-chloropropyl)-2- chlorophenothiazine. The results are discussed in terms of the classical PTC/OH− mechanisms.