Lewis base-catalyzed, asymmetric aldol additions of methyl ketone enolates

SE Denmark, RA Stavenger…

文献索引：Denmark, Scott E.; Stavenger, Robert A.; Wong, Ken-Tsung Journal of Organic Chemistry, 1998 , vol. 63, # 4 p. 918 - 919

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被引用次数: 79

摘要

The development of a general and highly effective catalytic asymmetric aldol addition reaction has been the subject of intense research in recent years. 1 Most strategies rely on a chiral Lewis acid to both activate the aldehyde and control the stereochemical course of the reaction. As these reactions most likely proceed through open transition structures where nonbonding interactions dominate, 2 acetate and methyl ketone substrates often perform ...