Synlett

A convenient protocol for the synthesis of hindered aryl malononitriles

A Schnyder, AF Indolese, T Maetzke, J Wenger…

文献索引：Schnyder, Anita; Indolese, Adriano F.; Maetzke, Thomas; Wenger, Jean; Blaser, Hans-Ulrich Synlett, 2006 , # 18 p. 3167 - 3169

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被引用次数: 10

摘要

Abstract A technically feasible method has been developed for the synthesis of variety of aryl malononitriles in high yields (70-95%) using the palladium-catalyzed coupling reaction of malononitrile with aryl bromides and chlorides, respectively. The influence a several reaction parameters such as base, ligand, solvent or temperature were investigated in some detail.