Structure–activity relationships in the acronycine and benzo [b] acronycine series: Role of the pyran ring

Q Do, HDT Mai, T Gaslonde, B Pfeiffer, S Léonce…

文献索引：Do, Quyen; Thi Mai, Huong Doan; Gaslonde, Thomas; Pfeiffer, Bruno; Leonce, Stephane; Pierre, Alain; Michel, Sylvie; Tillequin, Francois; Dufat, Hanh European Journal of Medicinal Chemistry, 2008 , vol. 43, # 12 p. 2677 - 2687

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被引用次数: 8

摘要

In order to explore the structure–activity relationships in the acronycine series, simplified analogues of cis-1, 2-diacetoxy-1, 2-dihydroacronycine and cis-1, 2-diacetoxy-1, 2- dihydrobenzo [b] acronycine (S23906-1, under clinical trials) lacking the fused pyran ring, but possessing an acetoxymethyl leaving group at position 4 were prepared. These new analogues only displayed marginal antiproliferative activity compared to the parent ...