Abstract The Grignard reagent made from p-cyclohexyl m-chloroiodobenzene is carbonated with 14 CO 2 to give 3-chloro 4-cyclohexyl benzoǐc acid (radioactive yield 50%). This acid is transformed into the corresponding chloride with thionyl chloride. Condensation of the chloride with tris-(trimethylsilyl) 1-lithio-1, 1, 2 ethane tricarboxylate gives after hydrolysis 4- (3-chloro 4-cyclohexyl phenyl) 4-oxobutyric acid 4-14 C with an overall yield of 41% ...
