Archiv der Pharmazie

Studies on Histaminergic Compounds, IV Non??isosterism between the Imidazole, Guanidino and Isothiourea Moieties at the H2??Receptor

…, H van Der Goot, H Timmerman

文献索引：Sterk; Van Der Groot; Timmerman Archiv der Pharmazie, 1986 , vol. 319, # 12 p. 1057 - 1064

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被引用次数: 5

摘要

Geert Jan Sterk, Henk van der Goot and Henk Timmerman* ... Vrije Universiteit, Department of Pharmacochemistry, De Boelelaan 1083, 108 1 HV Amsterdam, The Netherlands Eingegangen am 30. September 1985 ... S,S'-Alkylenediisothioureas were found to show only weak agonistic or antagonistic H,-activity, de- pending on the length of the alkylene chain. Introduction of a substituent in the amidino parts of both isothiourea groups resulted in a complete loss of the agonistic ...