Chemical and enzyme-catalysed syntheses of enantiopure epoxide and diol derivatives of chromene, 2, 2-dimethylchromene, and 7-methoxy-2, 2-dimethylchromene ( …
…, ND Sharma, R Boyle, TA Evans, JF Malone…
文献索引：Boyd, Derek R.; Sharma, Narain D.; Boyle, Rosemary; Evans, Timothy A.; Malone, John F.; McCombe, Kenneth M.; Dalton, Howard; Chima, Jagdeep Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 14 p. 1757 - 1765
Procaryotic (bacterial) dioxygenase-catalysed asymmetric dihydroxylation of chromene and 2, 2-dimethylchromene to yield the (4S)-enantiomers of the corresponding cis-diols exclusively is reported. The epoxide, and derived cis-and trans-diol products from the previously reported eucaryotic (mammalian) metabolism of precocene-1 (7-methoxy-2, 2- dimethylchromene), and the corresponding epoxide and diol derivatives of chromene and ...
