A number of fluorine-substituted uracil derivatives show interesting biological activity. For example, 5-fluorouracil derivatives are useful as antitumor agents, and 5-(trifluoromethy1) deoxyuridine shows marked antiviral activity. l,* The binding of 6-substituted uracil to thymidine phosphorylase has been studied. The 6-trifluoromethyl derivative has been reported to bind to this enzyme sevenfold better than the 6-methyl analogue. Presumably ...
[Mulder, Patrick P. J.; Boere, Ben B.; Baart, Arthur; Cornelisse, Jan; Lugtenburg, Johan Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 1 p. 22 - 32]
