Diels-Alder reactions of heterocyclic azadienes: total synthesis of PDE I, PDE II, and PDE I dimer methyl ester

DL Boger, RS Coleman

文献索引：Boger,D.L.; Coleman,R.S. Journal of the American Chemical Society, 1987 ,  vol. 109, p. 2717            

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被引用次数: 83

摘要

Abstract: Full details of the total synthesis of PDE I (2) and PDE I1 (3), two 3', 5'-CAMP phosphodiesterase inhibitors possessing the identical, functionalized 1, 2-dihydro-3H- pyrrolo [3, 2-e] indole structure constituting the central and right-hand segments of the potent antitumor antibiotic CC-1065 (l), are described. The linkage of two 1, 2-dihydro-3H-pyrrolo [3, 2-e] indole units in the preparation of PDE-I dimer methyl ester (4) is detailed and ...