Abstract A short and efficient asymmetric synthesis of enantiopure (S)-(+)-coniine is reported. Anodic cyanation of (-)-1-[(1S)-1-phenylethyl] piperidine, derived from [(1S)-1- phenylethyl] amine, results in regioselective formation of the corresponding α-aminonitrile, which was alkylated with propyl iodide to give a bifunctional derivative. The latter underwent a stereoselective reductive decyanation (80% de), the product of which was ...
