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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron

New syntheses of 2', 3'-dideoxy-2', 3'-di-substituted &-2'-mono-substituted uridines & adenosines by michael addition reactions

…, W Tong, JM Vial, G Remaud, J Chattopadhyaya

文献索引：Wu; Pathak; Tong; Vial; Remaud; Chattopadhyaya Tetrahedron, 1988 , vol. 44, # 21 p. 6705 - 6722

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被引用次数: 59

摘要

Michael addition reactions of the 3'-enesulfones 5, 6 and 18 with ammonia, primary amines (methylamine, benzylamine, glycine methyl ester), secondary amines (dimethylamine, pyrrolidine, piperidine, morpholine) and carbon-nucleophiles (sodium methylmalonate, conjugate base of nitromethane and pyrrolidin-1-cyclohexene) have been used as means to synthesize new 2', 3'-dideoxy-2', 3'-disubstituted-or 2'-substituted nucleosides. Most of ...

六氢吡啶结构式

1-(5'-trityl-2',3'-dideoxy-3'-toluenesulfonyl-β-D-glyceropent-2-enofuranosyl)uracil结构式

1-(5'-trityl-2'...

~96%

1-((2R,3S,4R,5R)-3-(piperidin-1-yl)-4-tosyl-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3S,4R,5R...

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5'-O-三苯甲基吡啶-2',3'-环己氧化物结构式

5'-O-三苯甲基吡啶-2',...

~%

1-((2R,3S,4R,5R)-3-(piperidin-1-yl)-4-tosyl-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3S,4R,5R...

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1-(5'-O-trityl-3'-deoxy-3'-(4-toluene)thio-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~%

1-((2R,3S,4R,5R)-3-(piperidin-1-yl)-4-tosyl-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3S,4R,5R...

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1-(5'-O-trityl-3'-deoxy-3'-toluenesulfonyl-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~%

1-((2R,3S,4R,5R)-3-(piperidin-1-yl)-4-tosyl-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3S,4R,5R...

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1-[2,3-di-O-(metanesulfonyl)-5-O-(triphenylmethyl)-β-D-ribofuranosyl]pyrimidine-2,4(1H,3H)-dione结构式

1-[2,3-di-O-(me...

~%

1-((2R,3S,4R,5R)-3-(piperidin-1-yl)-4-tosyl-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3S,4R,5R...

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1-(5'-O-trityl-3'-deoxy-3'-toluenesulfonyl-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~73%

1-(5'-trityl-2',3'-dideoxy-3'-toluenesulfonyl-β-D-glyceropent-2-enofuranosyl)uracil结构式

1-(5'-trityl-2'...

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5'-O-三苯甲基吡啶-2',3'-环己氧化物结构式

5'-O-三苯甲基吡啶-2',...

~%

1-(5'-trityl-2',3'-dideoxy-3'-toluenesulfonyl-β-D-glyceropent-2-enofuranosyl)uracil结构式

1-(5'-trityl-2'...

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1-(5'-O-trityl-3'-deoxy-3'-(4-toluene)thio-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~%

1-(5'-trityl-2',3'-dideoxy-3'-toluenesulfonyl-β-D-glyceropent-2-enofuranosyl)uracil结构式

1-(5'-trityl-2'...

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1-[2,3-di-O-(metanesulfonyl)-5-O-(triphenylmethyl)-β-D-ribofuranosyl]pyrimidine-2,4(1H,3H)-dione结构式

1-[2,3-di-O-(me...

~%

1-(5'-trityl-2',3'-dideoxy-3'-toluenesulfonyl-β-D-glyceropent-2-enofuranosyl)uracil结构式

1-(5'-trityl-2'...

查看详情

1-((2R,3S,4R,5R)-3-(piperidin-1-yl)-4-tosyl-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3S,4R,5R...

~28%

1-((2R,3R,5S)-3-(piperidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

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5'-O-三苯甲基吡啶-2',3'-环己氧化物结构式

5'-O-三苯甲基吡啶-2',...

~%

1-((2R,3R,5S)-3-(piperidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

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1-(5'-O-trityl-3'-deoxy-3'-(4-toluene)thio-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~96%

1-(5'-O-trityl-3'-deoxy-3'-toluenesulfonyl-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

查看详情

5'-O-三苯甲基吡啶-2',3'-环己氧化物结构式

5'-O-三苯甲基吡啶-2',...

~%

1-(5'-O-trityl-3'-deoxy-3'-toluenesulfonyl-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

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1-[2,3-di-O-(metanesulfonyl)-5-O-(triphenylmethyl)-β-D-ribofuranosyl]pyrimidine-2,4(1H,3H)-dione结构式

1-[2,3-di-O-(me...

~%

1-(5'-O-trityl-3'-deoxy-3'-toluenesulfonyl-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

查看详情

1-[2,3-di-O-(metanesulfonyl)-5-O-(triphenylmethyl)-β-D-ribofuranosyl]pyrimidine-2,4(1H,3H)-dione结构式

1-[2,3-di-O-(me...

~%

1-(5'-O-trityl-3'-deoxy-3'-(4-toluene)thio-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

查看详情

5'-O-三苯甲基吡啶-2',3'-环己氧化物结构式

5'-O-三苯甲基吡啶-2',...

~%

1-((2R,3R,5S)-3-morpholino-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

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1-(5'-O-trityl-3'-deoxy-3'-(4-toluene)thio-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~%

1-((2R,3R,5S)-3-morpholino-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

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1-(5'-trityl-2',3'-dideoxy-3'-toluenesulfonyl-β-D-glyceropent-2-enofuranosyl)uracil结构式

1-(5'-trityl-2'...

~%

1-((2R,3R,5S)-3-morpholino-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

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1-(5'-O-trityl-3'-deoxy-3'-toluenesulfonyl-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~%

1-((2R,3R,5S)-3-morpholino-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

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1-[2,3-di-O-(metanesulfonyl)-5-O-(triphenylmethyl)-β-D-ribofuranosyl]pyrimidine-2,4(1H,3H)-dione结构式

1-[2,3-di-O-(me...

~%

1-((2R,3R,5S)-3-morpholino-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

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1-(5'-O-trityl-3'-deoxy-3'-(4-toluene)thio-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~%

1-((2R,3R,5S)-3-(piperidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

查看详情

1-(5'-trityl-2',3'-dideoxy-3'-toluenesulfonyl-β-D-glyceropent-2-enofuranosyl)uracil结构式

1-(5'-trityl-2'...

~%

1-((2R,3R,5S)-3-(piperidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

查看详情

1-(5'-O-trityl-3'-deoxy-3'-toluenesulfonyl-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~%

1-((2R,3R,5S)-3-(piperidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

查看详情

1-[2,3-di-O-(metanesulfonyl)-5-O-(triphenylmethyl)-β-D-ribofuranosyl]pyrimidine-2,4(1H,3H)-dione结构式

1-[2,3-di-O-(me...

~%

1-((2R,3R,5S)-3-(piperidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

查看详情

5'-O-三苯甲基吡啶-2',3'-环己氧化物结构式

5'-O-三苯甲基吡啶-2',...

~%

1-((2R,3R,5S)-3-(pyrrolidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

查看详情

1-(5'-O-trityl-3'-deoxy-3'-(4-toluene)thio-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~%

1-((2R,3R,5S)-3-(pyrrolidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

查看详情

1-(5'-trityl-2',3'-dideoxy-3'-toluenesulfonyl-β-D-glyceropent-2-enofuranosyl)uracil结构式

1-(5'-trityl-2'...

~%

1-((2R,3R,5S)-3-(pyrrolidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

查看详情

1-(5'-O-trityl-3'-deoxy-3'-toluenesulfonyl-β-D-arabinofuranosyl)uracil结构式

1-(5'-O-trityl-...

~%

1-((2R,3R,5S)-3-(pyrrolidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

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1-[2,3-di-O-(metanesulfonyl)-5-O-(triphenylmethyl)-β-D-ribofuranosyl]pyrimidine-2,4(1H,3H)-dione结构式

1-[2,3-di-O-(me...

~%

1-((2R,3R,5S)-3-(pyrrolidin-1-yl)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione结构式

1-((2R,3R,5S)-3...

查看详情