From DMF to isatine: A novel and general one??pot synthesis of isatine and its N??unsubstituted derivatives via nucleophilic substitution reactions on 1, 2??bis ( …

SM Huber, A Hennig, FG Puehlhofer…

文献索引：Huber, Stefan M.; Hennig, Andre; Puehlhofer, Frank G.; Weiss, Robert Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 3 p. 421 - 427

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被引用次数: 1

摘要

Isatine 4 and its derivatives play an important role in the pharmaceutical and dye industry. Drugs containing isatine units cure diseases such as epilepsy [1], tuberculosis [2], and bulimia [3]. Isatin derivatives are furthermore employed as antibacterial [4] or antifugal [5] compounds or to treat inflammations [6]. Because of its importance, various synthetic routes to isatine and its derivatives have been developed. Although the large-scale synthesis of ...