[125I/127I] iodoHoechst 33342: Synthesis, DNA binding, and biodistribution

RS Harapanhalli, LW McLaughlin…

文献索引：Harapanhalli; McLaughlin; Howell; Rao; Adelstein; Kassis Journal of medicinal chemistry, 1996 , vol. 39, # 24 p. 4804 - 4809

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被引用次数: 61

摘要

An iodinated analog of the DNA-minor-groove-binding agent Hoechst 33342 has been synthesized and evaluated for DNA binding and tumor targeting. The bis-benzimidazole ring system of the title compound was constructed from the piperazinyl terminus via a Pinner-type cyclization followed by oxidative cyclization of the diamine Schiff base. To synthesize radioiodoHoechst 33342,(trimethylstannyl) Hoechst 33342 was prepared by the same ...