Preparation of 5-(2-Methoxy-4-nitrophenyl) oxazole: A Key Intermediate for the Construction of VX-497

RJ Herr, DJ Fairfax, H Meckler…

文献索引：Organic Process Research and Development, , vol. 6, # 5 p. 677 - 681

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被引用次数: 18

摘要

... from the acidic aqueous layer were examined (eg, extraction with other organic solvents, and ... After chromatographic purification, this procedure afforded the desired aryl aldehyde 8 as an orange ... Thus, this two-step process to provide 8 was achieved from commercially available ...