Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50= 3.3 μM) is the most potent GPa inhibitor. Preliminary structure–activity relationships of the oleanolic acid derivatives are discussed.
![齐墩果-12-烯[2,3-c][1,2,5]恶二唑-28-酸苯甲酯结构式](https://image.chemsrc.com/caspic/237/892869-54-4.png)
![12-烯并[2,3-c][1,2,5]氧二氮茂-28-齐墩果酸结构式](https://image.chemsrc.com/caspic/136/130216-69-2.png)
