A synthesis of atenolol using a nitrile hydration catalyst

J Akisanya, AW Parkins, JW Steed

文献索引：Akisanya, Joseph; Parkins, Adrian W.; Steed, Jonathan W. Organic Process Research and Development, 1998 , vol. 2, # 4 p. 274 - 276

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被引用次数: 30

摘要

The synthesis of atenolol is described using a platinum containing homogeneous catalyst for the conversion of a nitrile to an amide. The catalytic reaction may be employed as the final step in the synthesis or in the preparation of the intermediate 4-hydroxyphenylacetamide. The structure of the nitrile intermediate, 1-(4'-cyanomethylphenoxy)-2-hydroxy-3- isopropylaminopropane, has been determined by X-ray crystallography.