Tetrahedron

Synthesis of enantiopure 1-substituted, 1, 2-disubstituted, and 1, 4, 5-trisubstituted imidazoles from 1, 2-amino alcohols

Y Matsuoka, Y Ishida, D Sasaki, K Saigo

文献索引：Matsuoka, Yuki; Ishida, Yasuhiro; Sasaki, Daisuke; Saigo, Kazuhiko Tetrahedron, 2006 , vol. 62, # 34 p. 8199 - 8206

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被引用次数: 36

摘要

Synthetic strategies for the preparation of imidazoles with a stereogenic N-substituent are classified into two categories; (i) the alkylation of an imidazole nitrogen with enantiopure electrophiles and (ii) the cyclocondensation of ring fragments, typically the combination of glyoxal, ammonia, an aldehyde, and an enantiopure primary amine. The alkylation method is quite straightforward to access target molecules, because imidazole is commercially available and the N- ...