Identification of metabolites of azaperone in horse urine

…, JM Yang, HH Tai, A Jegananthan…

文献索引：Sams, Richard A.; Gerken, Diane F.; Detra, Randall L.; Stanley, Scott D.; Wood, William E.; Tobin, Thomas; Yang, Jyan-Ming; Tai, Hsin-Hsinng; Jegananthan, Alwarsamy; Watt, David S. Journal of Pharmaceutical Sciences, 1996 , vol. 85, # 1 p. 79 - 84

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被引用次数: 6

摘要

Abstract Two metabolites of the tranquilizer azaperone were extracted from alkalinized horse urine after treatment with β-glucuronidase/sulfatase from limpets (Patella vulgata). The metabolites were identified by a combination of independent chemical synthesis and GC/MS and 1 H NMR analysis. The metabolites were identified as 1-(fluorophenyl)-4-[4-(5-hydroxy- 2-pyridinyl)-1-piperazinyl]-1-butanol, designated as 5′-hydroxy-azaperol, and 1-( ...