Steroids

A practical Δ 1-dehydrogenation of Δ 4-3-keto-steroids with DDQ in the presence of TBDMSCl at room temperature

K Chen, C Liu, L Deng, G Xu

文献索引：Chen, Kaixiong; Liu, Chang; Deng, Le; Xu, Guangyu Steroids, 2010 , vol. 75, # 7 p. 513 - 516

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被引用次数: 13

摘要

Δ 1 -Dehydrogenation of abundantly available Δ 4 -3-keto-steroids for getting more effective therapeutic drugs is one of the important reactions in steroid chemistry [1]. Microbiological Δ 1 -dehydrogenation method is frequently used for the preparation of Δ 1,4 -3-keto-steroids [2] and [3]. The main disadvantage of this method is that large volumes of solution are required, and enzymes may create handling and stabilization difficulties. Moreover, ...