New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position
…, M Ludwikow, AT Fan, M Wang, SJ Hecker
文献索引：Cho, Aesop; Glinka, Tomasz W.; Ludwikow, Maria; Fan, Andrew T.; Wang, Michael; Hecker, Scott J. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 2 p. 137 - 140
We recently reported the discovery of RWJ-54428 (MC-02,479, 1), a new cephalosporin that displays potent activity against MRSA. 3 This compound has several unique structural features, notably a 4-pyridinethiol directly linked to the cephalosporin core (ie, no methylene spacer between them) and a 2-aminoethylthiomethyl substituent. The pyridine ring, in particular, proves to be crucial for both activity and solubility. We 4 and others 5 observed ...
