Journal of the American Chemical Society

Studies on the mechanism of ribonucleotide reductases

R Lenz, B Giese

文献索引：Lenz, Roman; Giese, Bernd Journal of the American Chemical Society, 1997 , vol. 119, # 12 p. 2784 - 2794

全文：HTML全文

被引用次数: 97

摘要

Ribonucleotide reductases are enzymes that catalyze the conversion of ribonucleotides to 2'- deoxyribonucleotides. This important reaction is initiated by the generation of a C- 3'nucleotide radical and subsequent loss of the 2'-hydroxyl group. In order to model certain steps in this mechanism, selenol ester 23 was prepared and photolyzed providing the first selective chemical access to the 3'-adenosyl radical. From product analysis it could be ...