Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: …

K Motoshima, M Ishikawa, Y Hashimoto…

文献索引：Motoshima, Kazunori; Ishikawa, Minoru; Hashimoto, Yuichi; Sugita, Kazuyuki Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3156 - 3172

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被引用次数: 7

摘要

Abstract Introduction of an alkylcarboxylic acid unit, which is a partial structure of endogenous peroxisome proliferator-activated receptor (PPAR) ligands, into a phenethylphenylphthalimide skeleton, which possesses liver X receptor (LXR) antagonistic activity, afforded novel PPAR ligands. The results of structure–activity relationship analysis and docking studies led us to the potent PPAR agonists 13c–e. The absolute configuration ...