Discovery of new inhibitors of aldose reductase from molecular docking and database screening

…, AM Ferrari, L Costantino, MC Gamberini

文献索引：Rastelli, Giulio; Ferrari, Anna Maria; Costantino, Luca; Gamberini, Maria Cristina Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1437 - 1450

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被引用次数: 46

摘要

Aldose reductase (ALR2) is a target enzyme for the treatment of diabetic complications. Owing to the limited number of currently available drugs for the treatment of diabetic complications, the discovery of new inhibitors of ALR2 that can potentially be optimized as drugs appears highly desirable. In this study, a molecular docking analysis of the structures of more than 127,000 organic compounds contained in the National Cancer Institute ...