The chiral tethered reaction is a versatile reaction design for asymmetric synthesis where strict stereocontrol can be achieved during the reaction between reagent and substrate elements con- nected by a chiral 2,4-pentanediol (PD) tether.1 Chiral cyclohep- tatrienes in optically active forms became available by applying this reaction design to the Büchner reaction.2,3 The PD-tethered carbenoid addition with 1 is highly stereocontrolled to result in a quantitative ...
